The Chancellor will today urge some America’s biggest investors to “stick with the UK” following last month’s resounding vote to quit the EU.
Mr Osborne told a US newspaper: “We will continue to be a beacon for free trade, democracy and security, more open to that world than ever.”
His message comes despite a series of doom-mongering claims about the economic impact of Brexit during the fraught referendum campaign.
Mr Osborne is believed to have spoken to Paul Ryan, speaker of the US House of Representatives, twice since the historic in/out vote.
The Chancellor will also meet Jack Lew, the US Treasury Secretary, in London before making other high-profile trips to China and Singapore.
Sources say the Chancellor wants to secure his own political future, possibly as Foreign Secretary, before a new Prime Minister is appointed.
Mr Osborne told the Wall Street Journal said: “One lesson of the referendum is that too many of our citizens feel economic progress is no longer benefiting them.
“Ever-higher welfare to make good lost incomes is not the answer – attracting private investment and good jobs beyond our major cities is.
“By managing day-to-day spending, we should commit to major investments in national infrastructure, including new roads, high-speed railways and digital networks.”
Barack Obama sparked widespread fury in April when claimed Brexit would put the UK at the “back of the queue” in any trade deal with the US.
Speaking from Downing Street, the US President said: “It’s fair to say that maybe some point down the line there might be a UK-US trade agreement.
“But it’s not going to happen any time soon because our focus is in negotiating with a big bloc, the European Union, to get a trade agreement done.”
But last week his trade chief opened the doors to Britain to join the Transatlantic Trade and Investment Partnership (TTIP) or Trans-Pacific Partnership (TPP).
Michael Froman said: “We’re certainly going to want to do whatever we can to deepen our relationship with the UK and as well as with the EU.
“Ultimately that could mean the UK joining TTIP when it’s completed. And I’ve even heard some people suggesting that they could join the TPP.”